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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAICS All Species: 30
Human Site: Y122 Identified Species: 55
UniProt: P22234 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22234 NP_001072992.1 425 47079 Y122 V K E G Y K F Y P P K V E L F
Chimpanzee Pan troglodytes XP_001140521 451 49634 Y148 V K E G Y K F Y P P K V E L F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532381 425 46974 Y122 V K E G Y K F Y P P K V E L F
Cat Felis silvestris
Mouse Mus musculus Q9DCL9 425 47052 Y122 V Q E G Y K F Y P P K V E M F
Rat Rattus norvegicus P51583 425 47078 Y122 V K E G Y R F Y P P K V E M F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516499 348 38076 K77 E E Q L I A S K L T F A G L T
Chicken Gallus gallus P38024 426 47222 Y123 V K E G Y K F Y P P K I E M F
Frog Xenopus laevis NP_001080163 425 47148 L122 V K E G Y K F L P P K V E T F
Zebra Danio Brachydanio rerio NP_955831 425 47059 T122 V K E G Y R F T P L K M E M F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9I7S8 429 47263 S127 V P E G Y R F S P P K Q E T F
Honey Bee Apis mellifera XP_624351 420 47251 N119 V P E G Y R F N P P L Q E T F
Nematode Worm Caenorhab. elegans Q10457 423 46959 N126 V K E G F R F N D L K L E T F
Sea Urchin Strong. purpuratus XP_780342 419 46499 A116 V H E G Y R F A P P K L E Y F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.1 N.A. 96.4 N.A. 95 96.2 N.A. 61.6 85.6 81.4 78.3 N.A. 58.7 54.5 49.6 62.1
Protein Similarity: 100 94 N.A. 98.3 N.A. 99.5 99 N.A. 69.6 92.4 90.3 91.7 N.A. 73.6 70.8 68.2 76
P-Site Identity: 100 100 N.A. 100 N.A. 86.6 86.6 N.A. 6.6 86.6 86.6 66.6 N.A. 66.6 60 53.3 66.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 20 100 86.6 86.6 N.A. 73.3 66.6 73.3 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 8 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 8 8 93 0 0 0 0 0 0 0 0 0 93 0 0 % E
% Phe: 0 0 0 0 8 0 93 0 0 0 8 0 0 0 93 % F
% Gly: 0 0 0 93 0 0 0 0 0 0 0 0 8 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 62 0 0 0 47 0 8 0 0 85 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 8 8 16 8 16 0 31 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 31 0 % M
% Asn: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 % N
% Pro: 0 16 0 0 0 0 0 0 85 77 0 0 0 0 0 % P
% Gln: 0 8 8 0 0 0 0 0 0 0 0 16 0 0 0 % Q
% Arg: 0 0 0 0 0 47 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 8 0 8 0 0 0 31 8 % T
% Val: 93 0 0 0 0 0 0 0 0 0 0 47 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 85 0 0 47 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _